274,275 Therapeutic strategies targeting oxidative stress and mitochondrial dysfunction include using antioxidants like alpha-lipoic acid (ALA), which improves neuropathic symptoms and nerve conduction velocities in patients with DPN
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These enzymes are the pyruvate dehydrogenase complex (PDHc) and 2-oxoglutarate (-ketoglutarate) dehydrogenase (OGDH), both of which are associated with the TCA cycle, and branched-chain ketoacid dehydrogenase (BCKD) necessary for metabolism of the branched-chain amino acids, leucine, isoleucine, and valine
How a B12 injection works Vitamin B12, also called cyanocobalamin, is essential for red blood cell production, nerve function, energy metabolism and the synthesis of DNA
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